Aguero sustained meniscus damage during last month’s 5-0 Premier League win over Burnley and was operated on by Guardiola’s preferred surgeon, Dr Ramon Cugat.
A four-to-six-week recovery period appeared to place Aguero in contention for the August 7 second leg with Madrid, which UEFA this week announced was clear to take place behind closed doors at the Etihad Stadium.
City hold a 2-1 advantage over the 13-time European champions but, after Friday’s draw paired the winner of their last-16 tie against Lyon or Juventus, they will have to try and seal a place at the final stages in Lisbon without their all-time record goalscorer.
“I told you many times no. [Defintely] no,” Guardiola told a news conference when asked about Aguero’ prospects.
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